Method in accordance with the model, insulin resistance can be divided into three kinds of model model of hereditary, genetically modified model and the induced model. Three kinds of models have their own characteristics and the scope of application of the genetic model of insulin resistance can be generated spontaneously, but costly, limiting their wide application in China. Genetically modified model is mainly used to study the mechanism of insulin resistance,

Background Insulin resistance is the metabolic syndrome, diabetes and atherosclerosis of the common pathological basis. Objective To compare the different body weight the same and different dietinduced body mass the same dietinduced insulin resistance rat model to establish the feasibility. Design, time and place Randomized controlled animal experiments, in 2006102007 ...

By Kono in 1991 equivalent to the use of the Department of LongEvans rats to establish an excellent rat model of insulin resistance. This model has more than food, obesity, polydipsia, polyuria and other characteristics, can be slow to naturally occurring type 2 diabetes. In the 14 weeks of age, the already existing insulin resistance, weight, and increased intraabdominal fat weight, while the existence of increased triglyceride and cholesterol, and

I personally think that the mouse model of insulin resistance is the key to the establishment of feed, high fat diet and the most important thing is the amount of salt. Molding on high fat diet, I think that the proportion of lard and sugar to a suitable, low temperature preservation is the key, not only can prevent fat rancidity material, you can help shape, I IR models in mice, in particular, there are a number of C57

The results showed that rats fed high fat diet by the glucose infusion rate was significantly lower than the ordinary diet of rats fed control and high fat diet feeding, the rats of the insulin sensitivity index decreased significantly, fasting plasma insulin increased significantly. The results show that fat can be fed with high fat diet rats to replicate the model of insulin resistance, and the method is simple,